Mysimba is a norepinephrine and dopamine reuptake inhibitor that combines naltrexone, which is used to treat opiate and alcohol addiction, with bupropion, which is used to treat depression and smoking addiction. It has been shown that two active chemicals control two major brain areas: the arcuate nucleus of the hypothalamus, which regulates food intake and energy expenditure. The mesolimbic pathway of the dopamine system is responsible for rewarding aspects of eating and eating-related stimuli. Only obese or overweight adults with one or more risk factors, such as hypertension, high cholesterol, or diabetes, will be eligible to Buy Mysimba.
It is a prescription drug consisting of two sustained-release molecules (naltrexone 8 mg and bupropion 90 mg). The combination of the two molecules has already been used in the US since 2014 and is currently the most prescribed non-generic drug in the US for weight loss. Bupropion is directed as an antidepressant and, in some instances, to help quit smoking.
Studies suggest that Weightloss with Mysimba acts in two areas of the brain involved in food intake:
- The hypothalamus.
- Reducing appetite and, therefore, food intake and the mesolimbic dopaminergic system.
- Reducing the desire to eat highly processed foods.
Mysimba is a medicine indicated, in addition to diet and physical activity, to promote weight management in adult patients: obese (with a BMI body mass index of 30 or more); overweight (BMI between 27 and 30) and with weight-related complications such as diabetes mellitus, abnormally high blood fat levels or high blood pressure.
The dosage, which at complete regimen consists of 2 tablets in the morning and two tablets in the evening, must be increased over four weeks, starting with one pill in the morning for a week; then one in the morning and one in the evening for another week; two in the morning and one in the evening for a third week, to reach the full dosage by the fourth week.
Clinical studies performed with this drug have shown, in addition to weight loss, positive effects on glycemic compensation in diabetic subjects, reduction of cholesterol and triglyceride levels in the blood, reduction of blood pressure. But the fact that anti-obesity drugs are usually studied in association with changes in lifestyle makes it difficult, if not impossible, to determine how much of the weight loss and associated parameters is due to the pill and how much to changes in diet or diet—physical activity. You can Buy Mysimba With an Online Prescription too.
The most common side effects are represented by: nausea, vomiting, abdominal pain, constipation of the hive, headache, anxiety, agitation, insomnia, and muscle and joint pain. These side effects are more common during the first month of treatment and tend to disappear during therapy. The drug should not be prescribed in case of previous seizures, suicidal thoughts or depression, use of opioid drugs or monoamine oxidase inhibitor (MAO) drugs, and in patients with renal impairment or severe hepatic insufficiency. The high cost, the still not perfectly known mechanism of action and the need to verify the long-term side effects place the drug, as a remedy to be used only after repeated failures of lifestyle change.